New biomarkers for MGN are being discovered, including some with strongerassociations with malignancies, such as anti-thrombospondin type 1 domain-containing7A (anti-THSD7A) antibody, which was detected in approximately 5–12% of patientswith MGN who are anti-PLA2r negative11,27. The gene discussed is PLA2R1; the disease is idiopathic membranous glomerulonephritis.