To assess the impact of lamin degradation on nuclear morphology, we applied the auxin-inducible degron (AID) system to HCT116 colorectal carcinoma epithelial cells to induce simultaneous degradation of lamin B1 and lamin B2 as previously described (Pujadas Liwag et al., 2024; Yesbolatova et al., 2019). The gene discussed is LMNB2; the disease is colorectal carcinoma.