According to another mechanism that relies on flotillins but not on their upregulation, Parkinson's disease‐associated DJ‐1/PARK7 deficiency is associated with flotillin 1 decrease and altered glutamate endocytosis that could exploit the role of flotillins as scaffolds of lipid raft domains (Kim et al., 2016). The gene discussed is FLOT1; the disease is Parkinson disease.