APP and early-onset autosomal dominant Alzheimer disease: Indeed, among the cargos of the flotillin‐mediated endocytic route, several proteins are deregulated in Alzheimer's disease, particularly APP, and in Parkinson's disease, particularly DAT, glutamate transporter, and α‐synuclein (Cremona et al., 2011; Kim et al., 2016; Kobayashi et al., 2019; Schneider et al., 2008).