Interestingly, Alzheimer's disease is associated with SphK2, a key player of the UFIT pathway, that unlike SphK1, is upregulated in brain samples from patients with Alzheimer's disease, and as a result leads to S1P overproduction in neurons (Takasugi et al., 2011). The gene discussed is MBTPS1; the disease is early-onset autosomal dominant Alzheimer disease.