IL1B and Alzheimer disease: In addition, the inoculation with S. aureus increased IL-1β and IL-18 production, whereas silencing of NLRP1 decreased the secretion of these cytokines in keratinocytes, suggesting that S. aureus may contribute to the pathogenesis of AD through NLRP1 inflammasome/IL-1β and IL-18 axis (Vaher et al., 2023).