Interestingly, S. epidermidis activates and upregulates Perforin-2 (P-2), while the upregulation of P-2 correlates with increased killing of intracellular S. aureus in skin cells, thereby protecting the host from skin infections (Strbo et al., 2019; Pastar et al., 2020). The gene discussed is MPEG1; the disease is skin infection.