After adjusting for confounding factors (age, male, BMI, smoking, hypertension, diabetes, WBC, Neu, PLT, CRP, Alb, BUN, lactate, APACHE II score, and SOFA score), the results indicated that an increase of either 1 unit or 1 SD in DLR was significantly and positively correlated with AKI occurrence (Supplementary Table 4). The gene discussed is CRP; the disease is hypertensive disorder.