Additionally, the levels of antioxidant enzymes in the hippocampus were measured using ELISA.<h4>Results</h4>The findings indicated that the T2D group had lower levels of antioxidant enzymes, Maf, Bcl2, PGC1α, and Nrf2, and higher levels of BAX and Keap1 in the hippocampus. Here, KEAP1 is linked to type 2 diabetes mellitus.