Most of the circRNAs mentioned in this review are overexpressed in glioma and contribute to therapeutic resistance by activation of divers signaling pathways, including the PI3K/AKT, Wnt-β-catenin, Notch and NF-κB, thus affecting cell survival, apoptosis, autophagy, EMT, and stemness. The gene discussed is AKT1; the disease is glioma.