Specifically, this study assesses the effects of combined treatment on ventricular arrhythmias, the expression of genes related to mitochondrial fission (Fis1; mitochondrial fission 1 protein, DRP; dynamin-related protein 1) and fusion (Mfn1; mitofusin 1, Mfn2; mitofusin 2), and oxidative stress in the aged rat heart exposed to IRI. This evidence concerns the gene FIS1 and Ventricular arrhythmia.