An increase in pro-inflammatory cytokines (such as IL-1β), various glycation products (especially MGO and AGEs), oxidized LDL, and FFA contribute to glycemia, insulin resistance, dyslipidemia, and obesity through activation of the hepatic NF-kβ pathway and reduction in GLUT4 gene expression (2, 19). Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.