Research has indicated that S100A8 and S100A9 are highly expressed in autoimmune diseases such as Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Psoriasis (Pa) and Juvenile Idiopathic Arthritis (SoJIA). The gene discussed is S100A9; the disease is systemic-onset juvenile idiopathic arthritis.