Research has indicated that S100A8 and S100A9 are highly expressed in autoimmune diseases such as Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Psoriasis (Pa) and Juvenile Idiopathic Arthritis (SoJIA). This evidence concerns the gene S100A8 and systemic-onset juvenile idiopathic arthritis.