BRCA1 and posterior cortical atrophy: Germline mutations in the BRCA1 and BRCA2 genes were present in 0.5%–2% of patients with PCa and were associated with more aggressive features and worse prognosis in PCa, while somatic mutations in BRCA1 or BRCA2 were present in 15%–25% of mCRPC.9, 10, 11, 12