TF and antiphospholipid syndrome: Although TG using CAT has been successful in reproducing some thrombotic disorders such as protein C or protein S deficiency, APC resistance (including FV Leiden) or the G20210A prothrombin gene mutation [[12], [13], [14], [15]], and antiphospholipid syndrome [16], it relies on an artificial procoagulant stimulus using exogenous TF at an arbitrary concentration and does not incorporate the pro- and anticoagulant properties of the endothelium.