Cardamonin targets Bcl-2 family proteins, activating the caspase cascade, inhibiting the nuclear translocation of NF-κB, STAT3 and mTOR, blocks β-catenin signaling, downregulating cell cycle regulatory proteins, and inhibiting oncogenic signaling to induce apoptosis and arrest the cell cycle, thus halting proliferation and metastasis in various cancer cell types (Javaria et al., 2020). This evidence concerns the gene NFKB1 and cancer.