On the other hand, we found that patients with lower CTLA4 expression but higher CD8+ TEM abundance had better prognosis than the patients with higher CTLA4 and high CD8+ TEM, rationalizing the CTLA4 blockade at the earlier stage of BLCA, We observed that the patients with higher expression of NKG2A (KLRC1) and TIGIT with higher CD56bright NK presence were predicted to have favourable prognosis over the patients with higher expression of these receptors but lower CD56bright NK cells. This evidence concerns the gene TIGIT and bladder transitional cell carcinoma.