On the basis of this we believe that HER2/CD47-specific CAR M, while sensing and clearing dead tumor or tumor containing neighboring (immune) cells, also skewed Th1 effector response including priming cytotoxic T lymphocytes (CD8+ T cells), secretion of major Th1 effectors viz TNF-α, and IFN-γ & IL-2, and concomitant neutralizing exhaustion markers like PD-1, TIGIT, and LAG-3 on tumor cells (20). The gene discussed is TNF; the disease is neoplasm.