In vitro: The study found that HSP90B1 is significantly upregulated in radioresistant GBM cell lines. HSP90B1 promotes the localization of GLUT1 on the plasma membrane, enhances glycolytic activity, and subsequently augments tumor growth and radioresistance in GBM cells.In vivo effects: In mouse models, HSP90B1 knockdown combined with radiotherapy (IR) improves survival rates in mice harboring GBM (48). The gene discussed is HSP90B1; the disease is glioblastoma.