Furthermore, changes in the cytotoxic capacity of exhausted CD8+ T cells after bryostatin-1 treatment was assessed by killing assay, in which we co-cultured bryostatin-1 or DMSO- treated exhausted OT-I cells with OVA(257-264) peptide pulsed AE-17 mesothelioma cells. Here, CD8A is linked to mesothelioma.