Our scRNA-seq data on the higher proportion of IL1B+ proinflammatory monocytes and CD8+ CCL4+ T cells in ACPA+ eRA are compatible to the previous reports (23), which indicates that the peripheral scRNA-seq landscape may be a molecular reflection of immunologic dysregulation in synovial compartment of RA patients, suggesting a possible communication between the periphery and the joints in establishing RA pathology. Here, ESR1 is linked to rheumatoid arthritis.