Tumor cells can show high-level PD-L1 to bind with PD-1 of T cells, causing programmed T cell deaths (Khalil DN et al., 2016; Jiang P et al., 2018), helping themseves adapt to challenges from T cells (Zou et al., 2016; Khalil DN et al., 2016; Jiang P et al., 2018). This evidence concerns the gene CD274 and neoplasm.