Ferroptosis-associated autophagy released High-mobility group box 1 (HMGB1) (Xue J et al., 2021) can not only elevate M1 polarization, but also enhance TNF-α secretion of TAMs in bladder cancer mediated by advanced glycosylation end product-specific rereceptor (AGER) (Wen Q et al., 2019). Here, HMGB1 is linked to urinary bladder cancer.