We characterized MEIS2 as a transcriptional regulator of experience-dependent PV IN plasticity in CA3/CA2 and demonstrated that Meis2-dependent restoration of experience-dependent PV IN plasticity in CA3/CA2 in adulthood in Cntnap2 KO mice is sufficient to reverse developmental deficits in excitation-inhibition balance, cognitive impairments and seizure risk. The gene discussed is CNTNAP2; the disease is Cognitive impairment.