We characterized MEIS2 as a transcriptional regulator of experience-dependent PV IN plasticity in CA3/CA2 and demonstrated that Meis2-dependent restoration of experience-dependent PV IN plasticity in CA3/CA2 in adulthood in Cntnap2 KO mice is sufficient to reverse developmental deficits in excitation-inhibition balance, cognitive impairments and seizure risk. This evidence concerns the gene MEIS2 and Cognitive impairment.