We then applied a bioinformatic pipeline to generate data-driven protein modules which resulted in the proteins being clustered into 5 modules that varied in their degree of association with age, race, CSF AD biomarkers (Aβ42, Tau, and pTau) and clinical phenotypes such as disease progression, cognitive function, and the Aβ42/Tau Ratio (TAR). The gene discussed is MAPT; the disease is Alzheimer disease.