CALR and systemic lupus erythematosus: Importantly, EBV infection and antibodies to EBNA-1 have been observed to occur before or at the onset of autoantibodies to Ro, and anti-EBNA-1 antibodies in healthy individuals rarely cross-react with Ro60 or induce autoimmunity, indicating a SLE-specific mechanism of molecular mimicry for EBNA-1 [49].