In rat PD models induced by rotenone (Wang et al., 2022), 6-hydroxydopamine (6-OHDA) (Kin et al., 2021; Hosomoto et al., 2023) or combination of DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) and 6-OHDA (Farrand et al., 2020), VNS consistently improves cylinder test (Farrand et al., 2020; Kin et al., 2021; Hosomoto et al., 2023), rotation test (Kin et al., 2021; Hosomoto et al., 2023), and open field test (Wang et al., 2022). The gene discussed is DUSP26; the disease is Parkinson disease.