The RAS-ERK and PI3K-phosphatidylinositol 3 kinase-mammalian target of rapamycin (mTOR) signaling pathways are the cell's chief mechanisms for controlling cell survival, differentiation, proliferation, metabolism, and motility in response to extracellular cues; the activation of RAS increases some pathways, controlled by PI3K-mTOR, that induce growth, and there is a strong link between metabolic rewiring in cancer and such pathways (45). This evidence concerns the gene MTOR and cancer.