Many factors can affect the level of sex hormone binding globulin, such as age, gender, endocrine status, etc. The change of its level may be related to some diseases, such as polycystic ovary syndrome, hypogonadism, etc. The primary indicators of insulin resistance include diminished glucose uptake and suppression of hepatic glycogenolysis and peripheral tissue gluconeogenesis. The gene discussed is SHBG; the disease is polycystic ovary syndrome.