CD4 and type 1 diabetes mellitus: The percentage of CD4+CD25high T cells in FDRs1 was significantly lower compared to control subjects, FDRs0 as well as patients with R-T1D in IRS and CR (FDRs1: 1.1 (0.925–1.2) vs CTR: 2.36(1.09–4.09) (p<0.01), FDRs1: 1.1 (0.925–1.2) vs FDRs0 2.31 (1.71–3.29) (p<0.001), FDRs1: 1.1 (0.925–1.2) vs R-T1D IRS: 2.18 (1.61–2.93) (p<0.001) FDRs1: 1.1 (0.925–1.2) vs CR: 2.33 (1.99–2.56) % (<0.001) (Figure 2, Table 2).