found that procyanidin B, a selectiveinhibitor of NLRP3 inflammatory vesicle activity,inhibits the assembly and activation of this inflammatoryvesicle, which ultimately reduces urinary protein,blood creatinine, and blood urea nitrogen in micewith lupus nephritis (glomerulonephritis) model, aswell as reduces immune complex deposition andglomerular injury in renal tissue. The gene discussed is NLRP3; the disease is lupus nephritis.