Anlotinib hydrochloride is a type of tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR) and stem cell factor receptor (c-Kit), which can inhibit both tumor angiogenesis and tumor growth simultaneously (8). This evidence concerns the gene KDR and neoplasm.