Among the downregulated genes were paraoxonase 1 (Pon1), an antioxidative protein associated with lower activity in AMD (37) and potentially linked to oxidative stress, which has been reported in myopia (38); and retinoic acid early transcript 1E (Raet1e), which is intriguing as retinoic acid signaling has been implicated in myopia (39). The gene discussed is RAET1E; the disease is age-related macular degeneration.