HMGB1 is a core factor mediating programmed cell death in various cells, and the nucleus-to-cytoplasm translocation of HMGB1 in neurons and glial cells may be an important trigger for status epilepticus (Pauletti et al., 2019; Chen et al., 2023; Tang et al., 2023). The gene discussed is HMGB1; the disease is status epilepticus.