Suberoylanilide hydroxamic acid has been shown to prevent astrocyte and microglia activation, which can alleviate ischemia-induced neuroinflammation by inhibiting the deacetylation activity of HDAC1/2 (Dai et al., 2021), while the class IIa HDAC inhibitor MC1568 attenuates ischemic stroke-induced ferroptosis of cortical neurons by blocking HDAC9 transcription (Sanguigno et al., 2023). This evidence concerns the gene HDAC9 and ischemia.