The Nucleotide-binding oligomerization domain-like receptor family card domain-containing protein (NLRP3) inflammasome is an important activator of pyroptosis related to epilepsy, and it has been demonstrated that STAT3 can promote the expression of NLRP3 by catalyzing the acetylation of histone H3K9 on the NLRP3 promoter, thereby activating the NLRP3/caspase-1 pathway and exacerbating the damage to neurons in epileptic mice (Jiang et al., 2021). This evidence concerns the gene NLRP3 and epilepsy.