Given the well-established detrimental interplay between inflammation and seizures in epilepsy (Löscher and Brandt, 2010; Vezzani, 2020), it is plausible that the reduction in DCX+ cell density in seizing mice reflects a combined seizures-inflammation phenotype rather than being attributable to either condition alone or to specific seizures related parameters. The gene discussed is DCX; the disease is epilepsy.