Furthermore, proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the progression and dissemination of colon cancer cells through its modulation of epithelial-mesenchymal transition and the PI3K/AKT signaling pathway in tumor cells, as well as influencing the phenotypic polarization of macrophages. Here, PCSK9 is linked to malignant colon neoplasm.