Furthermore, proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the progression and dissemination of colon cancer cells through its modulation of epithelial-mesenchymal transition and the PI3K/AKT signaling pathway in tumor cells, as well as influencing the phenotypic polarization of macrophages. This evidence concerns the gene PCSK9 and colonic neoplasm.