For rs1105569, the lead variant was in strong LD (r2 > 0.80) with 18 nonsynonymous variants (missense, frameshift, and nonsense) in CRHR1, SPPL2C, and MAPT. 49These three genes, and several others in 17q21.31, were previously considered important for COVID-19.10 The gene discussed is SPPL2C; the disease is COVID-19.