Complementing this with public multi‐omics datasets, we identified activation of transforming growth factor beta (TGFβ) signaling to be more strongly activated in MSS patients, whereas Janus kinase (JAK)–signal transducer and activator of transcription (STAT) and mitogen‐activated protein kinase (MAPK) molecular cascades were activated specifically in MSI tumors. The gene discussed is TGFB1; the disease is Marinesco-Sjogren syndrome.