CD8A and acute myeloid leukemia: CD8+ Tconv cells pre-cultured in the DNT+AMLsupernatant induced significant cytotoxicity against AML cells while pre-treating AML cells with DNT+AMLsupernatant did not affect CD8+ Tconv cell-mediated cytotoxicity (Fig. 2C), demonstrating that DNTs promote the anti-leukemic activity of CD8+ Tconv cells directly rather than sensitizing AML cells to CD8+ Tconv cell-mediated cytotoxicity.