To determine whether the soluble factors secreted by DNTs upon encountering AML cells sensitize AML cells to CD8+ Tconv cell-mediated cytotoxicity or induce the anti-leukemic activity of CD8+ Tconv cells, AML cells, CD8+ Tconv cells or both were cultured in supernatants taken from DNT alone culture (DNTsupernatant) or DNT + AML co-culture (DNT+AMLsupernatant) for 24 h. This evidence concerns the gene CD8A and acute myeloid leukemia.