CD8A and acute myeloid leukemia: Given that DNTs can enhance the anti-leukemic activity of CD8+ Tconv cells, we concurrently studied the impact of DNTs on GvHD-inducing activities of Tconv cells in the AML xenograft model presented in Fig. 1A, by analyzing the liver and lung tissues harvested from the leukemia-bearing mice treated with PBMC + PBS or PBMC + DNT for the degree of tissue damage (Fig. 3A).