CD8A and acute myeloid leukemia: Similarly, the cytotoxicity of CD8+ Tconv cells isolated from MLR conducted in the presence of AE-DNTs against allo-PBMC was significantly higher compared to those stimulated with allo-antigen in the presence of DNTs, suggesting that DNTs have a reduced capacity to suppress alloreactive Tconv cells after encountering AML cells (Fig. 5F).