In addition to being highly enriched in CTNNB1 (Catenin Beta 1), a key player in maintaining BBB integrity through cell adhesion pathways, a recent study found that BEC transcriptomes from five different cortical regions were upregulated in protein folding genes and had a distinct response to amyloid pathology regardless of brain region [94]. The gene discussed is CTNNB1; the disease is amyloidosis.