In BATF3-deficient mice, bone marrow-derived DCs fail to produce IL-12 upon Toll-like receptor 3 (TLR3) stimulation, and these mice exhibit significantly weakened CD8+T cell responses to West Nile virus and tumor-specific CD8+T cell responses to syngeneic fibrosarcoma [53]. The gene discussed is CD8A; the disease is fibrosarcoma.