NLRP3 and acute myeloid leukemia: In line with this, we observed signs of senescence including reduced expression of Retinoblastoma protein (Rb) in MOLM-13 cells (Fig. 1f) and upregulation of GLB1, TP53 and CDKN1A in all tested AML cell lines after NLRP3 inhibition (Fig. 1g).