Interestingly, the combination of NLRP3 inhibitors including CP-456773, CY-09 and Disulfiram with low concentrations of Midostaurin and Quizartinib specifically and significantly enhanced apoptosis in FLT3-ITD AML cell lines, leaving FLT3-wt cells unaffected. This evidence concerns the gene FLT3 and acute myeloid leukemia.