In line with this, we observed signs of senescence including reduced expression of Retinoblastoma protein (Rb) in MOLM-13 cells (Fig. 1f) and upregulation of GLB1, TP53 and CDKN1A in all tested AML cell lines after NLRP3 inhibition (Fig. 1g). This evidence concerns the gene CDKN1A and acute myeloid leukemia.