In line with this, we observed signs of senescence including reduced expression of Retinoblastoma protein (Rb) in MOLM-13 cells (Fig. 1f) and upregulation of GLB1, TP53 and CDKN1A in all tested AML cell lines after NLRP3 inhibition (Fig. 1g). The gene discussed is RB1; the disease is acute myeloid leukemia.