ICAM1 and cancer: As inhibition of enhanced ICAM1 expression in mice fed a CDAA diet for 1 week significantly reduced B16F10Luc2 cell retention, we forward the hypothesis that mechanical retention followed by endothelial adhesion molecule- and integrin-mediated firm adhesion is necessary to permit definitive seeding of cancer cells to the premetastatic hepatic vascular niche prepared by early MASH.