Ponath et al. demonstrated that a known MS-risk variant (rs7665090G) located near NFKB1 increased NF-κB signaling in MS lesions and associated with decreased astrocyte glutamate uptake and lactate release in vitro, highlighting direct detrimental effects on astrocyte homeostatic functions important for neuronal health [78]. This evidence concerns the gene NFKB1 and myeloid sarcoma.