TCRMOGNlrx1−/− mice showed a significant loss of RGCs compared to TCRMOGNlrx1+/+ mice (Fig. 3I), suggesting that in the absence of NLRX1, MOG-specific T-cells can also lead to optic neuropathy independent from spinal cord pathology. The gene discussed is NLRX1; the disease is optic nerve disorder.