Additionally, we observed an unexpected significant decrease in RGC density in IgHMOGNlrx1−/− control mice compared to IgHMOG Nlrx1+/+ control mice (Fig. 3H), suggesting that in the setting of NLRX1 loss and associated immune dysregulation, anti-MOG immunoglobulins can lead to some degree of optic neuropathy. The gene discussed is NLRX1; the disease is optic nerve disorder.