The canonical NF-κB signaling pathway is one important innate immune activation signaling pathway that is highly activated in MS disease-associated astrocytes and microglia in the brain parenchyma, particularly beneath meningeal lymphoid aggregates; at the lesion edge of slowly expanding lesions; and in the optic nerves in MS, as well as in EAE [7–10, 68]. This evidence concerns the gene NFKB1 and myeloid sarcoma.