Huang et al. investigated the role of MTHFR C677T and A1298C polymorphisms in colorectal adenomas and colorectal cancers, and it showed a small but significant negative correlation between CRC and TT genotypes (OR 0.93, 95% CI: 0.89, 0.97), which was in agreement with the results of our study [125]. The gene discussed is MTHFR; the disease is colorectal cancer.