CASP3 and Parkinson disease: Confirming our previous findings of higher levels of aggregated αSyn conformers in SNCA locus duplication mDANs from an additional PD patient and establishing increased ROS probe levels, reduced ATP signals, and increased caspase-3 activation, we recapitulate neuropathological hallmarks of PD in human iPSC-derived mDANs from a patient with monoallelic SNCA locus duplication and characterize a phenotype potentially amenable to treatment with the αSyn misfolding inhibitor.