To evaluate the response of myricetin on PC associated genes, BACH2, PAX5, BCL6, IRF4, BLIMP1, XBP1, and the ER stress gene IRE1a (Inositol-Requiring Enzyme 1a (IRE1a) which is responsible for XBP1 splicing. The gene discussed is PAX5; the disease is pachyonychia congenita.