ERBB2 and breast neoplasm: Upon conducting immunohistochemical (IHC) staining of 25 resected breast tumor tissues covering clinical subtypes including triple-negative, HER2 + , Luminal-A, and Luminal-B, we found that the hSPAR levels were dramatically reduced in all the tested breast tumoral tissues as compared to non-tumoral tissues (Figs. 1E and  EV1B).