CDKN1B and cancer: The cyclin-dependent kinase inhibitor 1B (CDKN1B or P27KIP1) was initially identified as a cyclin-dependent kinase inhibitor (CDKi) and is frequently found to be mis-regulated in cancer cells (Alkarain and Slingerland, 2004; Besson et al, 2008; Chu et al, 2008; Razavipour et al, 2020).