Finally, we analyzed data from the publicly available TCGA CRC dataset and found that the mRNA level of SP1 was positively correlated with the mRNA levels of classical YAP/TEAD target genes, such as CTGF, CYR61, and AXL, as well as the YAP signature (7 classical YAP/TEAD target genes) in CRC (Fig. 7A and Supplementary Fig. S7A). Here, CCN2 is linked to colorectal carcinoma.