WT1 and inflammatory bowel disease: Using the homologous gud/gar genes garD, gudD, and garR as a reference database, we mapped the stool metagenomic reads from 1261 metagenomes of Human Microbiome Project 2 (HMP2) data (UC n = 337, CD n = 565, non-IBD n = 359) and determined that the genes in the gud/gar pathway are found in higher relative abundance in IBD patients compared to non-IBD patients (Mann U Whitney test, CD p = 6.181e-08 W = 122,824, UC p = 0.01763 W = 54,200, UC-CD p = 0.008988 W = 105,092) (Fig. 8A).