PPARGC1A and ischemic stroke: However, it is extremely interesting to observe that, the disruption in the ATP/ADP ratio occurring during the ischemic stroke [19], correlates with AMP-activated kinase (AMPK) activation and the consequent regulation of mitochondrial biogenesis by phosphorylating and activating the transcriptional factor peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) [42].