Among them, it has been proposed that the E3-ligase Siah1/2 (seven in absentia homolog-1/2), recruited on mitochondria after depolarization and able to ubiquitinate mitochondrial proteins, activates mitophagy in different pathological conditions like Parkinson’s Disease and cerebral ischemia [38, 39]. The gene discussed is SIAH1; the disease is Parkinson disease.