UBQLN2 and amyotrophic lateral sclerosis: Whiteley et al. demonstrated that RTL8A-C decreased but PEG10 increased in the differentiated neurons of ALS patient iPSCs, suggesting that PEG10 is a direct target of ubiquitin-like protein (ubiquilin) 2, UBQLN2 [23], a major gene for responsible for ALS [28], and also that RTL8A-C is protected from proteasome-dependent degradation by complex formation with UBQLN2.