It is consistent with previous reports that human RTL8A-C protein is expressed in the neurons differentiated from AS and ALS patient iPSCs (iNeurons) [22,23] and also with the fact that human RTL8A/8B are involved in the nuclear transition of UBQLN2 that is necessary for nuclear protein quality control [29]. Here, RTL8A is linked to amyotrophic lateral sclerosis.