Both GABRB2 and ADRA1A have been reported to be associated with several psychiatric disorders: the former with SZ, BP, FTD and ASD [34–42] and the latter with attention deficit hyperactivity disorder (ADHD), SZ and generalized anxiety disorder (GAD) [58–60], thus making them good candidates for the DKO phenotypes. The gene discussed is GABRB2; the disease is generalized anxiety disorder.