Ogino et al. found that HLA-1 was downregulated in over 65% of NPC samples, and the infiltration of CD8+ T-cells was significantly correlated with the expression of HLA-1 (r = 0.34),11 suggesting that defect of HLA-1 is a significant mechanism of immune evasion in NPC. The gene discussed is CD8A; the disease is nasopharyngeal carcinoma.