Transient receptor potential isoform 7 (Trpc7) enriches in striatal regions, depolarizes the membrane potential, activates or inactivates voltage-gated Ca2+ channels, and regulates multiple cellular functions.32, 33, 34 miR-873-5p and miR-330-3p can regulate PIK3/AKT/mTOR, NF-κβ, Wnt/β-catenin, and MEK/ERK signaling pathways to affect cancer cell proliferation, migration, invasion, stemness, and glycolysis.35, 36 miR-34a-5p can suppress PTEN-induced kinase-1 (Pink1) expression to inhibit the Pink1-mediated mitophagy process.37 The gene discussed is MAP2K7; the disease is cancer.